The Relationship between Social Anxiety and Conforming behavior in a computerized task

This study assessed the relationship between social anxiety symptoms and conforming behavior in both ambiguous and unambiguous computerized context. The majority of the participants for the sample consisted of Caucasian (78%) females (71%) who completed the task entirely (N = 94). Measures of the Social Phobia Inventory (SPIN) were used to assess social anxiety, while a computer mediated problem-solving task was used to assess conforming behavior. It was hypothesized that conforming behavior would be greater in the ambiguous context compared to the unambiguous context; and that social anxiety scores would be correlated with higher conforming behavior. While a Wilcoxon analysis concluded that higher conforming behavior was observed in the ambiguous than the unambiguous context (p \u3c .001), there was no significant correlation between social anxiety scores and conforming behavior observed. Results, clinical implications, and directions for future research are discussed

Scale Model Thruster Acoustic Measurement Results

The Space Launch System (SLS) Scale Model Acoustic Test (SMAT) is a 5% scale representation of the SLS vehicle, mobile launcher, tower, and launch pad trench. The SLS launch propulsion system will be comprised of the Rocket Assisted Take-Off (RATO) motors representing the solid boosters and 4 Gas Hydrogen (GH2) thrusters representing the core engines. The GH2 thrusters were tested in a horizontal configuration in order to characterize their performance. In Phase 1, a single thruster was fired to determine the engine performance parameters necessary for scaling a single engine. A cluster configuration, consisting of the 4 thrusters, was tested in Phase 2 to integrate the system and determine their combined performance. Acoustic and overpressure data was collected during both test phases in order to characterize the system's acoustic performance. The results from the single thruster and 4- thuster system are discussed and compared

Scale Model Thruster Acoustic Measurement Results

Subscale rocket acoustic data is used to predict acoustic environments for full scale rockets. Over the last several years acoustic data has been collected during horizontal tests of solid rocket motors. Space Launch System (SLS) Scale Model Acoustic Test (SMAT) was designed to evaluate the acoustics of the SLS vehicle including the liquid engines and solid rocket boosters. SMAT is comprised of liquid thrusters scalable to the Space Shuttle Main engines (SSME) and Rocket Assisted Take Off (RATO) motors scalable to the 5-segment Reusable Solid Rocket Motor (RSTMV). Horizontal testing of the liquid thrusters provided an opportunity to collect acoustic data from liquid thrusters to characterize the acoustic environments. Acoustic data was collected during the horizontal firings of a single thruster and a 4-thruster (Quad) configuration. Presentation scope. Discuss the results of the single and 4-thruster acoustic measurements. Compare the measured acoustic levels of the liquid thrusters to the Solid Rocket Test Motor V - Nozzle 2 (SRTMV-N2)

The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: Mock galaxy catalogues for the BOSS Final Data Release

We reproduce the galaxy clustering catalogue from the SDSS-III Baryon Oscillation Spectroscopic Survey Final Data Release (BOSS DR11 and DR12) with high fidelity on all relevant scales in order to allow a robust analysis of baryon acoustic oscillations and redshift space distortions. We have generated (6000) 12 288 MultiDark PATCHY BOSS (DR11) DR12 light cones corresponding to an effective volume of ~ 192 000 [h-1 Gpc]3 (the largest ever simulated volume), including cosmic evolution in the redshift range from 0.15 to 0.75. The mocks have been calibrated using a reference galaxy catalogue based on the halo abundance matching modelling of the BOSS DR11 and DR12 galaxy clustering data and on the data themselves. The production follows three steps. First, we apply the PATCHY code to generate a dark matter field and an object distribution including non-linear stochastic galaxy bias. Secondly, we run the halo/stellar distribution reconstruction HADRON code to assign masses to the various objects. This step uses the mass distribution as a function of local density and non-local indicators (i.e. tidal field tensor eigenvalues and relative halo exclusion separation for massive objects) from the reference simulation applied to the corresponding patchy dark matter and galaxy distribution. Finally, we apply the SUGAR code to build the light cones. The resulting MultiDarkPATCHY mock light cones reproduce the number density, selection function, survey geometry, and in general within 1s, for arbitrary stellar mass bins, the power spectrum up to k = 0.3 h Mpc-1, the two-point correlation functions down to a few Mpc scales, and the three-point statistics of the BOSS DR11 and DR12 galaxy samples.Fil: Kitaura, Francisco-Shu. Leibniz-Institut für Astrophysik Potsdam; AlemaniaFil: Rodriguez Torres, Sergio A.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Chuang, Chia Hsun. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Zhao, Cheng. Tsinghua University; ChinaFil: Prada, Francisco. Consejo Superior de Investigaciones Científicas; España. Universidad Autónoma de Madrid; EspañaFil: Gil Marín, Héctor. University of Portsmouth; Reino UnidoFil: Guo, Hong. State University of Utah; Estados Unidos. Shanghai Astronomical Observatory; ChinaFil: Yepes, Gustavo. Universidad Autónoma de Madrid. Facultad de Ciencias; EspañaFil: Klypin, Anatoly. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España. New Mexico State University; Estados UnidosFil: Scoccola, Claudia Graciela. Universidad Autónoma de Madrid; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Instituto de Astrof{isica de Canarias; España. Universidad de La Laguna; EspañaFil: Tinker, Jeremy. University of New York; Estados UnidosFil: McBride, Cameron. Harvard-Smithsonian Center for Astrophysics; Estados UnidosFil: Reid, Beth. Lawrence Berkeley National Laboratory; Estados Unidos. University of California at Berkeley; Estados UnidosFil: Sánchez, Ariel G.. Max Planck Institut für Extraterrestrische Physik; AlemaniaFil: Salazar Albornoz, Salvador. Max Planck Institut für Extraterrestrische Physik; Alemania. Ludwig Maximilians Universitat; AlemaniaFil: Grieb, Jan Niklas. Max Planck Institut für Extraterrestrische Physik; Alemania. Ludwig Maximilians Universitat; AlemaniaFil: Vargas Magana, Mariana. Universidad Nacional Autónoma de México; MéxicoFil: Cuesta, Antonio J.. Universidad de Barcelona; EspañaFil: Neyrinck, Mark. University Johns Hopkins; Estados UnidosFil: Beutler, Florian. Lawrence Berkeley National Laboratory; Estados UnidosFil: Comparat, Johan. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Percival, Will J.. University of Portsmouth; Reino UnidoFil: Ross, Ashley. Ohio State University; Estados Unidos. University of Portsmouth; Reino Unid

The clustering of galaxies in the completed SDSS-III Baryon Oscillation Spectroscopic Survey: tomographic BAO analysis of DR12 combined sample in configuration space

We perform a tomographic baryon acoustic oscillations analysis using the two-point galaxy correlation function measured from the combined sample of BOSS DR12, which covers the redshift range of $0.2<z<0.75$. Splitting the sample into multiple overlapping redshift slices to extract the redshift information of galaxy clustering, we obtain a measurement of $D_A(z)/r_d$ and $H(z)r_d$ at nine effective redshifts with the full covariance matrix calibrated using MultiDark-Patchy mock catalogues. Using the reconstructed galaxy catalogues, we obtain the precision of $1.3\%-2.2\%$ for $D_A(z)/r_d$ and $2.1\%-6.0\%$ for $H(z)r_d$. To quantify the gain from the tomographic information, we compare the constraints on the cosmological parameters using our 9-bin BAO measurements, the consensus 3-bin BAO and RSD measurements at three effective redshifts in \citet{Alam2016}, and the non-tomographic (1-bin) BAO measurement at a single effective redshift. Comparing the 9-bin with 1-bin constraint result, it can improve the dark energy Figure of Merit by a factor of 1.24 for the Chevallier-Polarski-Linder parametrisation for equation of state parameter $w_{\rm DE}$. The errors of $w_0$ and $w_a$ from 9-bin constraints are slightly improved when compared to the 3-bin constraint result.Comment: 14 pages, 21 figures, 7 Tables. Submitted to MNRA

HTS-Compatible Patient-Derived Cell-Based Assay to Identify Small Molecule Modulators of Aberrant Splicing in Myotonic Dystrophy Type 1

Myotonic dystrophy type 1 (DM1) is a genetic disorder characterized by muscle wasting, myotonia, cataracts, cardiac arrhythmia, hyperinsulinism and intellectual deficits, and is caused by expansion of a CTG repeat in the 3’UTR of the Dystrophia Myotonica-Protein Kinase (DMPK) gene. The DMPK transcripts containing expanded CUG repeats accumulate in nuclear foci and ultimately cause mis-splicing of secondary genes through the dysregulation of RNA-binding proteins including Muscleblind 1 (MBNL1) and CUG binding protein 1 (CUGBP1). Correction of mis-splicing of genes such as the Skeletal muscle-specific chloride channel 1 (CLCN1), Cardiac troponin T (TNNT2), Insulin receptor (INSR) and Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 1 (SERCA1) may alleviate some of the symptoms of DM1; hence identification of small molecule modulators is an important step towards a therapy for DM1 patients. Here we describe the generation of immortalized myoblast cell lines derived from healthy (DMPK CTG5) and DM1 patient (DMPK CTG1000) fibroblasts by constitutive overexpression of human telomerase reverse transcriptase (hTERT) and inducible overexpression of the Myoblast determination factor (MYOD). MBNL1-containing nuclear foci, mis-splicing events and defective myotube differentiation defects characteristic of DM1 were observed in these cells. A CLCN1 luciferase minigene construct (CLCN1-luc) was stably introduced to monitor intron 2 retention in the DM1 cellular context (a reported splicing defect in DM1). The assay was validated by performing a high-throughput screen (HTS) of ~13,000 low molecular weight compounds against the CLCN1-luc DM1 myoblast cell line, providing an ideal system for conducting HTS to better understand and treat DM1

Spectroscopy, MOST Photometry, and Interferometry of MWC 314: Is it an LBV or an interacting binary?

MWC 314 is a bright candidate luminous blue variable that resides in a fairly close binary system, with an orbital period of 60.753$\pm$0.003 d. We observed MWC 314 with a combination of optical spectroscopy, broad-band ground- and space-based photometry, as well as with long baseline, near-infrared interferometry. We have revised the single-lined spectroscopic orbit and explored the photometric variability. The orbital light curve displays two minima each orbit that can be partially explained in terms of the tidal distortion of the primary that occurs around the time of periastron. The emission lines in the system are often double-peaked and stationary in their kinematics, indicative of a circumbinary disc. We find that the stellar wind or circumbinary disc is partially resolved in the K\prime-band with the longest baselines of the CHARA Array. From this analysis, we provide a simple, qualitative model in an attempt to explain the observations. From the assumption of Roche Lobe overflow and tidal synchronisation at periastron, we estimate the component masses to be M1 $\approx 5$ M$_\odot$ and M2$\approx 15$ M$_\odot$, which indicates a mass of the LBV that is extremely low. In addition to the orbital modulation, we discovered two pulsational modes with the MOST satellite. These modes are easily supported by a low-mass hydrogen-poor star, but cannot be easily supported by a star with the parameters of an LBV. The combination of these results provides evidence that the primary star was likely never a normal LBV, but rather is the product of binary interactions. As such, this system presents opportunities for studying mass-transfer and binary evolution with many observational techniques.Comment: 26 pages, 7 figures, 5 tables, 2 appendices with 7 additional tables and 2 additional figures. Accepted for publication in MNRA